MULTIPLE SCLEROSIS DEVELOPING IN PATIENT WITH AUTOIMMUNE HEPATITIS

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Segue abaixo resumo de um dos trabalhos elaborados pela equipe do CIEM apresentados no BCTRIMS 2015:



INTRODUCTION:

Although liver dysfunction most commonly occurs in multiple sclerosis (MS) patients due to adverse effects of disease-modifying-therapy, neurologists are to be aware that it may also derive from direct autoimmune damage. Autoimmune hepatitis (AH) is a chronic inflammation of the liver that affects children and adults. It may be associated with a variety of conditions such as thyroiditis, myasthenia gravis and rheumatoid arthritis. The association of AH and MS is rare and usually occurs in patients under treatment with immunomodulatory drugs or steroids which may act as trigger agents. Herein we report a young patient who presented AH and 24 years later developed MS. To our knowledge MS development after AH for such a long interval has not been reported in the literature.