AREA POSTREMA SYNDROME AS PREDICTIVE FACTOR OF OUTCOME IN NEUROMYELITIS OPTICA SPECTRUM DISORDERS

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Segue abaixo resumo de um dos trabalhos elaborados pela equipe do CIEM apresentados no BCTRIMS 2015:

Introduction:

 

Neuromyelitis optica spectrum disorders (NMOSD) are mostly frequent characterized by attacks of optic neuritis and transverse myelitis that may cause severe disability. Identification of predictive factors of outcome may provide physicians with tools to develop strategies to choose prophylactic treatments more timely and appropriately. Area postrema syndrome (APS) has recently been recognized as a frequent sign of dorsal brainstem involvement in NMOSD patients. It more commonly occurs in AQP4-IgG seropositive patients and may be the inaugural symptom of the disease or even antedate any other disease manifestation. We retrospectively looked at a group of seropositive NMOSD patients with brainstem symptoms to analyze disability during the course of the disease. We compared disability scores in patients who presented with those who did not present area postrema syndrome.