NEUROMYELITIS OPTICA SPECTRUM DISORDERS PHENOTYPE IN ANTI-MOG SEROPOSITIVE PATIENTS

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Segue abaixo resumo de um dos trabalhos elaborados pela equipe do CIEM apresentados no BCTRIMS 2015:



Background:

Neuromyelitis optica spectrum disorders (NMOSD) are frequently associated with anti-aquaporin 4 (anti-AQP4) autoimmunity. Recently, some patients with full or limited NMOSD phenotype who are seropositive to myelin oligodendrocyte glycoprotein antibody (anti-MOG IgG) and seronegative to anti-AQP4 IgG have been described in different countries suggesting that this association is a worldwide phenomenon, occurring in most ethnic groups. Herein we describe a series of patients who exhibited NMOSD phenotype and were found to be anti-AQP4 IgG seronegative and anti-MOG IgG seropositive. The present series is compared to cases previously reported in the literature.